| PMID |
Curator |
System |
Sentence |
| 15078078 |
Yes |
Yes |
The potential of embryonic stem (ES) cells to differentiate into inner ear hair cells was examined in this study. |
| 15078073 |
Yes |
Yes |
To examine whether hair cell immunophenotypes could be derived from the central nervous system (CNS), we established cell cultures from embryonic day 16.5 fetal rat brain tissues, and analyzed changes in immunohistochemical features of the CNS cell cultures by induction of differentiation. |
| 15078073 |
Yes |
No |
These findings indicate that immature neural progenitors possess the potential to differentiate into hair cell phenotypes. |
| 15078071 |
Yes |
Yes |
Expression of beta-catenin was examined together with the expression of Ki-67, a marker for proliferating cells, or myosin VIIa, a marker for differentiated hair cells. |
| 15078071 |
Yes |
Yes |
In addition, during differentiation and maturation of hair cells, the area of beta-catenin expression was further limited. |
| 14699969 |
No |
No |
Further analysis of the patterns of afferent fiber losses in mutations that do not develop differentiated hair cells shows that the expression of neurotrophins is remarkably strong and can support afferent innervation. |
| 14699969 |
Yes |
Yes |
Indeed, BDNF may be one of the earliest genes expressed selectively in hair cells and it appears to be regulated somewhat independently of the genes needed for hair cell differentiation. |
| 14662166 |
Yes |
Yes |
Instead of preventing cell loss, we must consider methods of stimulating cell division and hair cell differentiation from existing cells. |
| 14593207 |
Yes |
No |
Generation of hair cells by stepwise differentiation of embryonic stem cells. |
| 14593207 |
Yes |
No |
We further demonstrate that cells that express markers characteristic of hair cells differentiate from embryonic stem cell-derived progenitors. |
| 14578428 |
Yes |
Yes |
Previous studies have shown that the USH1-proteins myosin VIIa, harmonin, and cadherin 23 interact and form a functional network during hair cell differentiation in the inner ear. |