| PMID |
Curator |
System |
Sentence |
| 15096815 |
No |
Yes |
Foscarnet used in salvage therapy of HIV-1 patients harbouring multiple nucleotide excision mutations. |
| 14981049 |
Yes |
No |
We examined the expression of IMPDH1, IMPDH2 and HPRT transcripts, encoding enzymes of the de novo and salvage pathways of guanine nucleotide biosynthesis, respectively, in retinal sections of mice, the data indicating that the bulk of GTP within photoreceptors is generated by IMPDH1. |
| 14977562 |
Yes |
Yes |
De-novo synthesis, salvage, and degradation of both purine and pyrimidine nucleotides are operative at all stages of somatic embryo maturation and germination. |
| 14977562 |
Yes |
Yes |
The early phases of embryo development are accompanied by a decreased salvage activity of purine nucleotides, which reflects a reduction of cell proliferation and the initiation of organized growth. |
| 14977562 |
No |
Yes |
The operative salvage pathway in dried embryos is needed for the enlargement of the nucleotide pool necessary to sustain the reactivation of the overall cellular metabolism at germination, before the reactivation of the de-novo pathway, which is a later event. |
| 14729341 |
Yes |
Yes |
In the absence of the de novo purine nucleotide biosynthetic pathway in parasitic protozoa, purine salvage is of primary importance for parasite survival. |
| 14687575 |
No |
Yes |
This reaction allows the synthesis of ribose from other sugars, as well a means for salvage of carbohydrates after nucleotide breakdown. |
| 14660729 |
No |
No |
There were also 2 cell lines in which TK(1) activity changed little as cells moved from the plateau phase to exponential growth, suggesting that in these cell lines, de novo nucleotide synthesis pathways predominate over salvage pathways. |
| 14658380 |
Yes |
Yes |
Nucleotides are synthesized both from amino acids and other small molecules via de novo pathways, and from preformed nucleobases and nucleosides by salvage pathways. |