Evaluation: for terms not in GO (not yet validated terms)

[45] spindle positioning and orientation
  Sentence Validation
PMID Curator System Sentence
15146058 Yes Yes In case of altered spindle orientation, the spindle position checkpoint inhibits Tem1-dependent activation of the mitotic exit network (MEN), thus delaying mitotic exit and cytokinesis until errors are corrected.
15004232 No Yes Although cells deleted for either mbo1(+) or gfh1(+) are viable, they exhibit a number of defects associated with altered microtubule function such as defects in cell polarity, nuclear positioning, spindle orientation, and cleavage site specification.
14573349 No No In most cell types, the position of the mitotic spindle at the onset of anaphase dictates the orientation of the division axis; in unicellular organisms, it plays an important role in chromosome segregation.
12517707 Yes Yes For some of these processes, the position and orientation of the mitotic spindle must be coupled to cell polarity for correct positioning of daughter cells and inheritance of localised molecules.
11950945 No Yes Reorientation of mispositioned spindles in short astral microtubule mutant spc72Delta is dependent on spindle pole body outer plaque and Kar3 motor protein.
11784116 No Yes We show that the Rac gene ced-10 and the Rac-related gene mig-2 are redundantly required for the proper orientation of certain vulval cell divisions, suggesting a role in spindle positioning.
11245579 Yes Yes The accurate segregation of these determinants relies on proper orientation of the mitotic spindle within the dividing neuroblast, and on the correct positioning of the cleavage plane.
11231580 Yes Yes Distinct roles for Galpha and Gbetagamma in regulating spindle position and orientation in Caenorhabditis elegans embryos.
11231580 Yes Yes Correct placement and orientation of the mitotic spindle is essential for segregation of localized components and positioning of daughter cells.