| PMID |
Curator |
System |
Sentence |
| 15146058 |
Yes |
Yes |
In case of altered spindle orientation, the spindle position checkpoint inhibits Tem1-dependent activation of the mitotic exit network (MEN), thus delaying mitotic exit and cytokinesis until errors are corrected. |
| 15004232 |
No |
Yes |
Although cells deleted for either mbo1(+) or gfh1(+) are viable, they exhibit a number of defects associated with altered microtubule function such as defects in cell polarity, nuclear positioning, spindle orientation, and cleavage site specification. |
| 14573349 |
No |
No |
In most cell types, the position of the mitotic spindle at the onset of anaphase dictates the orientation of the division axis; in unicellular organisms, it plays an important role in chromosome segregation. |
| 12517707 |
Yes |
Yes |
For some of these processes, the position and orientation of the mitotic spindle must be coupled to cell polarity for correct positioning of daughter cells and inheritance of localised molecules. |
| 11950945 |
No |
Yes |
Reorientation of mispositioned spindles in short astral microtubule mutant spc72Delta is dependent on spindle pole body outer plaque and Kar3 motor protein. |
| 11784116 |
No |
Yes |
We show that the Rac gene ced-10 and the Rac-related gene mig-2 are redundantly required for the proper orientation of certain vulval cell divisions, suggesting a role in spindle positioning. |
| 11245579 |
Yes |
Yes |
The accurate segregation of these determinants relies on proper orientation of the mitotic spindle within the dividing neuroblast, and on the correct positioning of the cleavage plane. |
| 11231580 |
Yes |
Yes |
Distinct roles for Galpha and Gbetagamma in regulating spindle position and orientation in Caenorhabditis elegans embryos. |
| 11231580 |
Yes |
Yes |
Correct placement and orientation of the mitotic spindle is essential for segregation of localized components and positioning of daughter cells. |